Then there's Inwood, a bustling enclave in northern Manhattan. Afterward, catch a concert at the legendary Apollo Theater.

Head north above 110th Street to enjoy Harlem's Restaurant Row, the center of the area's burgeoning culinary scene. Guggenheim Museum and the Metropolitan Museum of Art. Across town is the Upper East Side and its Museum Mile, which features two biggies: the Solomon R. The Upper West Side is brimming with cultural offerings, including the American Museum of Natural History and Lincoln Center for the Performing Arts. Uptown neighborhoods are just as distinctive. Several blocks south is the arts district, Chelsea, where both galleries and shops are steps away from the High Line, an elevated park.

Meanwhile, Hudson Yards, Manhattan's newest destination, is known for its lofty condos, luxurious shopping (hello Neiman Marcus), and the Vessel, a climbable landmark. The West Village, with its charming cobblestone streets, is the East Coast birthplace of the gay rights movement. Hit the streets of the Lower East Side to discover a thriving nightlife scene, where music venues like the Bowery Ballroom feature well-known indie bands. But what truly defines the borough is its neighborhoods.

Just mention New York City to tourists and locals alike, and they'll envision the best attractions in Manhattan, from the Whitney Museum of American Art to the Sky Portal at One World Observatory.

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